Title:	Influence of the body mass and visceral adiposity on glucose metabolism in obese women with Pro12Pro genotype in PPARgamma2 gene.
Authors:	KAIPPERT, V. C. UEHARA, S. K. D'ANDREA, C. L. NOGUEIRA, J. LAGO, M. F. do LOPES, M. C. O. dos S. OLIVEIRA, E. M. M. ROSADO, E. L.
Affiliation:	VANESSA CHAIA KAIPPERT, UFRJ; SOFIA KIMI UEHARA, UFRJ; CARLA LIMA D'ANDREA, UFRJ; JULIANA NOGUEIRA, UFRJ; MÁRCIA FÓFANO DO LAGO, UFRJ; MARCELLY CUNHA OLIVEIRA DOS SANTOS, UFRJ; EDNA MARIA MORAIS OLIVEIRA, CTAA; ELIANE LOPES ROSADO, UFRJ.
Date Issued:	2013
Citation:	Nutrición Hospitalaria, Madrid, v. 28, n. 3, p. 694-700, 2013.
Description:	Introduction: Glucose metabolism may be altered in obesity and genotype for PPAR 2 can influence this variable. Objective: To evaluate the influence of body mass (BM) and visceral adiposity (VA) in glucose metabolism in morbid obese women with Pro12Pro genotype. Methods: Were selected 25 morbidly obese women. Groups were formed according to body mass index (BMI) [G1: 40-45 kg/m2 (n = 17); G2: > 45 kg/m2 (n = 8)]. Anthropometric, glycemia and insulinemia assessments (fasting, 60 and 120 minutes after high polyunsaturated fatty acids meal) were carried out. The insulin resistance (IR) and insulin sensitivity (IS) were assessed by HOMA-IR and QUICKI respectively. Results: G2 had higher BMI and waist circumference, compared to G1, impaired fasting glucose, low IS and higher IR. The postprandial glucose was normal, but there was a higher insulin peak one hour after the meal in G2. Conclusion: Increased BM and VA were associated with worse glucose metabolism suggesting metabolic differences between morbid obese with Pro12Pro genotype.
Thesagro:	Obesidade
Keywords:	Índice de massa corporal Resistência à insulina Metabolismo da glicose PPARgamma
DOI:	10.3305/nh.2013.28.3.6372
Type of Material:	Artigo de periódico
Access:	openAccess
Appears in Collections:	Artigo em periódico indexado (CTAA)