Title:	Bayesian model combining linkage and linkage disequilibrium analysis for low density-based genomic selection in animal breeding.
Authors:	SILVA, F. F. JEREZ, E. A. Z. RESENDE, M. D. V. de VIANA, J. M. S. AZEVEDO, C. F. LOPES, P. S. NASCIMENTO, M. LIMA, R. O. de GUIMARÃES, S. E. F.
Affiliation:	Fabyano Fonseca Silva, UFV; Elcer Albenis Zamora Jerez, UFV; MARCOS DEON VILELA DE RESENDE, CNPF; José Marcelo Soriano Viana, UFV; Camila Ferreira Azevedo, UFV; Paulo Sávio Lopes, UFV; Moysés Nascimento, UFV; Rodrigo Oliveira de Lima, UFV; Simone Eliza Facioni Guimarães, UFV.
Date Issued:	2018
Citation:	Journal of Applied Animal Research, v. 46, n. 1, p. 873-878, 2018.
Description:	We combined linkage (LA) and linkage disequilibrium (LDA) analyses (emerging the term ?LALDA?) for genomic selection (GS) purposes. The models were fitted to a simulated dataset and to a real data of feed conversion ratio in pigs. Firstly, the significant QTLs (quantitative trait locus) were identified through LA-based mixed models considering the QTL-genotypes as random effects by means of genotypic identity by descent matrix. This matrix was calculated at the positions of significant QTLs (based on LA) allowing to include the QTL-genotype effects additionally to SNP (single nucleotide polymorphism) markers (based on LDA) and additive polygenic effects in several GS models (Bayesian Ridge Regression ? BRR; Bayes A ? BA; Bayes B ? BB; Bayes C ? BC and Bayesian LASSO ? BL). These models combing all mentioned effects were denominated LALDA. Goodness-of-fit and predictive ability analyses were performed to evaluate the efficiency of these models. For the real data, although slightly, the superiority of the LALDA models was verified in comparison to traditional LDA models for GS. For the simulated dataset, the models presented similar results. For both LDA and LALDA frameworks, BA showed the best fitting through Deviance Information Criterion and higher predictive ability in the simulated and real datasets.
Keywords:	x
DOI:	10.1080/09712119.2017.1415903
Type of Material:	Artigo de periódico
Access:	openAccess
Appears in Collections:	Artigo em periódico indexado (CNPF)