Please use this identifier to cite or link to this item: http://www.alice.cnptia.embrapa.br/alice/handle/doc/1131052
Research center of Embrapa/Collection: Embrapa Meio Ambiente - Artigo em periódico indexado (ALICE)
Date Issued: 2021
Type of Material: Artigo em periódico indexado (ALICE)
Authors: MEDEIROS, A. M. Z.
KHAN, L. U.
SILVA, G. H. da
OSPINA, C. A.
ALVES, O. L.
CASTRO, V. L. S. S. de
MARTINEZ, D. S. T.
Additional Information: ALINE MARIA ZIGIOTTO DE MEDEIROS, CNPEM; LATIF ULLAH KHAN, CNPEM; GABRIELA HELENA DA SILVA, CNPEM; CARLOS ALBERTO OSPINA, CNPEM; OSWALDO LUIZ ALVES, IQ-UNICAMP; VERA LUCIA SCHERHOLZ S DE CASTRO, CNPMA; DIEGO STÉFANI TEODORO MARTINEZ, CNPEM.
Title: Graphene oxide-silver nanoparticle hybrid material: an integrated nanosafety study in zebrafish embryos.
Publisher: Ecotoxicology and Environmental Safety, v. 209, article 111776, 2021.
Language: Ingles
Keywords: Nanohybrids
Nanoecotoxicology
Nanotoxicity
Alternative methods
Grafeno
Nanomateriais.
Description: Abstract: This work reports an integrated nanosafety study including the synthesis and characterization of the graphene oxide-silver nanoparticle hybrid material (GO-AgNPs) and its nano-ecotoxicity evaluation in the zebrafish embryo model. The influences of natural organic matter (NOM) and a chorion embryo membrane were considered in this study, looking towards more environmentally realistic scenarios and standardized nanotoxicity testing. The nanohybrid was successfully synthesized using the NaBH4 aqueous method, and AgNPs (~ 5.8 nm) were evenly distributed over the GO surface. GO-AgNPs showed a dose-response acute toxicity: the LC50 was 1.5 mg L-1 for chorionated embryos. The removal of chorion, however, increased this toxic effect by 50%. Furthermore, the presence of NOM mitigated mortality, and LC50 for GO-AgNPs changed respectively from 2.3 to 1.2 mg L-1 for chorionated and de-chorionated embryos. Raman spectroscopy confirmed the ingestion of GO by embryos; but without displaying acute toxicity up to 100 mg L-1, indicating that the silver drove toxicity down. Additionally, it was observed that silver nanoparticle dissolution has a minimal effect on these observed toxicity results. Finally, understanding the influence of chorion membranes and NOM is a critical step towards the standardization of testing for zebrafish embryo toxicity in safety assessments and regulatory issues.
Thesagro: Composto de Carbono
Toxidez
Peixe de Água Doce
NAL Thesaurus: Ecotoxicology
Graphene oxide
Nanomaterials
Danio rerio
chorion.
Data Created: 2021-04-05
ISSN: 0147-6513
Appears in Collections:Artigo em periódico indexado (CNPMA)

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