Título:	Genome-wide analyses reveal the genetic architecture and candidate genes of indicine, taurine, synthetic crossbreds, and locally adapted cattle in Brazil.
Autoria:	VERARDO, L. L. SILVA, F. F. e MACHADO, M. A. PANETTO, J. C. do C. REIS, D. R. de L. OTTO, P. I. REGITANO, L. C. de A. SILVA, L. O. C. da EGITO, A. A. do ALBUQUERQUE, M. do S. M. ZANELLA, R. SILVA, M. V. G. B.
Afiliação:	LUCAS LIMA VERARDO, Universidade Federal dos Vales do Jequitinhonha e Mucuri FABYANO FONSECA E SILVA, Universidade Federal de Viçosa MARCO ANTONIO MACHADO, CNPGL JOAO CLAUDIO DO CARMO PANETTO, CNPGL DANIELE RIBEIRO DE LIMA REIS FAZA, CNPGL PAMELA ITAJARA OTTO, Universidade Federal de Santa Maria LUCIANA CORREIA DE ALMEIDA REGITANO, CPPSE LUIZ OTAVIO CAMPOS DA SILVA, CNPGC ANDREA ALVES DO EGITO, CNPGC MARIA DO SOCORRO MAUÉS ALBUQUERQUE RICARDO ZANELLA, Universidade de Passo Fundo MARCOS VINICIUS GUALBERTO B SILVA, CNPGL.
Ano de publicação:	2021
Referência:	Frontiers in Genetics, v. 12, article 702822, 2021.
Conteúdo:	Cattle population history, breeding systems, and geographic subdivision may be reflected in runs of homozygosity (ROH), effective population size (Ne), and linkage disequilibrium (LD) patterns. Thus, the assessment of this information has become essential to the implementation of genomic selection on purebred and crossbred cattle breeding programs. In this way, we assessed the genotype of 19 cattle breeds raised in Brazil belonging to taurine, indicine, synthetic crossbreds, and Iberian-derived locally adapted ancestries to evaluate the overall LD decay patterns, Ne, ROH, and breed composition. We were able to obtain a general overview of the genomic architecture of cattle breeds currently raised in Brazil and other tropical countries. We found that, among the evaluated breeds, different marker densities should be used to improve the genomic prediction accuracy and power of genome-wide association studies. Breeds showing low Ne values indicate a recent inbreeding, also reflected by the occurrence of longer ROH, which demand special attention in the matting schemes to avoid extensive inbreeding. Candidate genes (e.g., ABCA7, PENK, SPP1, IFNAR1, IFNAR2, SPEF2, PRLR, LRRTM1, and LRRTM4) located in the identified ROH islands were evaluated, highlighting biological processes involved with milk production, behavior, rusticity, and fertility. Furthermore, we were successful in obtaining the breed composition regarding the taurine and indicine composition using single-nucleotide polymorphism (SNP) data.
Thesagro:	Bovino Gado Genética Animal Genoma Produção Leiteira Comportamento Animal Fertilidade Animal
NAL Thesaurus:	Homozygosity Population size Linkage disequilibrium Milk production Animal behavior Animal fertility
Palavras-chave:	Rusticidade Rusticity
Digital Object Identifier:	https://doi.org/10.3389/fgene.2021.702822
Tipo do material:	Artigo de periódico
Acesso:	openAccess
Aparece nas coleções:	Artigo em periódico indexado (CNPGL)