Title:	Detection of antileukemia metabolites from P. limosum integrating genome mining, metabolomic analysis and cytotoxicity assays.
Authors:	BASSICHETO, M. OLIVEIRA, C. RIVERO, M. SIPOLONI, V. SOARES, J. K. C. SILVA, G. F. da JUSTO, G. VEIGA, T. SOMAN, L.
Affiliation:	MILENA BASSICHETO, UNIVERSIDADE FEDERAL DE SÃO PAULO; CLÁUDIA OLIVEIRA, UNIVERSIDADE FEDERAL DE SÃO PAULO; MILENA RIVERO, UNIVERSIDADE FEDERAL DE SÃO PAULO; VICTOR SIPOLONI, UNIVERSIDADE FEDERAL DE SÃO PAULO; JULLIO KENNEDY CASTRO SOARES, UNIVERSIDADE FEDERAL DE SÃO PAULO; GILVAN FERREIRA DA SILVA, CPAA; GISELLE JUSTO, UNIVERSIDADE FEDERAL DE SÃO PAULO; THIAGO VEIGA, UNIVERSIDADE FEDERAL DE SÃO PAULO; LÍVIA SOMAN, UNIVERSIDADE FEDERAL DE SÃO PAULO.
Date Issued:	2023
Citation:	In: BRAZILIAN CONFERENCE ON NATURAL PRODUCT (BCNP), 9. MEETING ON MICROMOLECULAR EVOLUTION, SYSTEMATICS AND ECOLOGY (RESEM), 35., 2023, Salvador. Proceedings [...] Campinas: Galoá, 2023.
Description:	Chemical dereplication and genome mining approaches were applied to detect cytotoxic metabolites produced by P. limosum CMLD 19 with anticancer potential against human leukemia cells. During the ongoing study, metabolites such as fumitremorgin and triprostatin were detected in the rice extract of P. limosum which showed 80% of cell inhibition for different human leukemia cell lines.
NAL Thesaurus:	Leukemia Genome mining
Keywords:	Cytotoxic metabolites Chemical dereplication
Type of Material:	Resumo em anais e proceedings
Access:	openAccess
Appears in Collections:	Resumo em anais de congresso (CPAA)