Title:	Evidence of vertical transmission of Senecavirus A in naturally infected sows.
Authors:	SCHAEFER, R. GAVA, D. BOMBASSARO, G. E. HAACH, V. MACIAG, S. S. BASTOS, A. P. A.
Affiliation:	REJANE SCHAEFER, CNPSA; DANIELLE GAVA, B UNIVERSIDADE FEDERAL DO RIO GRANDE DO SU; GABRIELLY E. BOMBASSARO, UNIVERSIDADE FEDERAL DO RIO GRANDE DO SUL; VANESSA HAACH, UNIVERSIDADE FEDERAL DO RIO GRANDE DO SUL; SHAIANA SALETE MACIAG, UNIVERSIDADE ESTADUAL DO CENTRO-OESTE DO PARANA; ANA PAULA ALMEIDA BASTOS, CNPSA.
Date Issued:	2024
Citation:	Virology, v. 600, n. 110248, 2024.
Description:	Abstract: Senecavirus A (SVA) is a Picornaviridae RNA virus that causes vesicular disease (VD) and transitory neonatal losses in pigs. The major ways SVA is spread are by oral, nasal, and feces. Vertical transmission of SVA was investigated during a VD epidemic in a farrow-to-finish herd in Brazil. Vesicular lesions were observed on sows before farrowing and on piglets within 24 h of birth. Analyses included RT-qPCR, viral isolation, sequencing, and virus-neutralization assays on serum, vesicular fluid, colostrum, and milk. Five out of ten sows were viremic before farrowing, and 46.7% of tested piglets had high viral loads in the first 24 h after birth. Infectious virus was detected in colostrum and milk from one postnatal sow. Despite high levels of neutralizing antibodies (nAbs) in piglet serum, colostrum, and milk, piglets were not protected from viremia and clinical illness. These findings support the vertical and congenital transmission of SVA.
Thesagro:	Leitão Colostro Virologia Transmissão de Doença
NAL Thesaurus:	Colostrum Piglets
Keywords:	Virolactia Senecavirus A Vertical transmission
DOI:	https://doi.org/10.1016/j.virol.2024.110248
Type of Material:	Artigo de periódico
Access:	openAccess
Appears in Collections:	Artigo em periódico indexado (CNPSA)