Título:	UPLC-QTOF-MS/MS and antifungal activity of a fraction enriched in saponins from Sarcomphalus joazeiro against Candida spp.
Autor:	SILVA, A. R. P. da COSTA, M. do S. ARAÚJO, N. J. S. ALENCAR, G. G. MOURA, T. F. FONSECA, V. J. A. SANTOS, A. T. L. dos MORAIS-BRAGA, M. F. B. SOUZA, E. O. de TAVARES, J. F. RIBEIRO, P. R. V. ANDRADE-PINHEIRO, J. C. COUTINHO, H. D. M.
Afiliación:	ANA RAQUEL PEREIRA DA SILVA, UNIVERSIDADE ESTADUAL DO CEARÁ; MARIA DO SOCORRO COSTA, UNIVERSIDADE ESTADUAL DO CEARÁ; NARA JULIANA SANTOS ARAÚJO, UNIVERSIDADE FEDERAL DO CARIRI; GABRIEL GONÇALVES ALENCAR, UNIVERSIDADE REGIONAL DO CARIRI; TALYSSON FELISMINO MOURA, UNIVERSIDADE REGIONAL DO CARIRI; VICTOR JUNO ALENCAR FONSECA, UNIVERSIDADE REGIONAL DO CARIRI; ANTÔNIA THASSYA LUCAS DOS SANTOS, UNIVERSIDADE REGIONAL DO CARIRI; MARIA FLAVIANA BEZERRA MORAIS-BRAGA, UNIVERSIDADE REGIONAL DO CARIRI; ERLÂNIO OLIVEIRA DE SOUZA, FACULDADE DE TECNOLOGIA DO CARIRI; JOSEAN FECHINE TAVARES, UNIVERSIDADE FEDERAL DA PARAÍBA; PAULO RICELI VASCONCELOS RIBEIRO, CNPAT; JACQUELINE COSMO ANDRADE-PINHEIRO, UNIVERSIDADE FEDERAL DO CARIRI; HENRIQUE DOUGLAS MELO COUTINHO, UNIVERSIDADE REGIONAL DO CARIRI.
Año:	2026
Referencia:	Biomedical Chromatography, v. 40, n. 7, e70509, July 2026.
Descripción:	The development of antifungal resistance is a complex process that involves the interaction between hosts, drugs, and microbial factors, all of which contribute to therapeutic ineffectiveness. For this reason, studies on natural products as possible therapeutic alternatives are increasingly necessary in order to gain a better understanding of plant compounds that may be more effective in treating infections caused by fungal pathogens. In this context, this study aimed to investigate the antifungal potential of the saponin-enriched fraction of the Sarcomphalus joazeiro species against the Candida albicans, Candida tropicalis, and Candida krusei strains. The selection of this species for study is due to its rich phytochemical composition and the vast traditional knowledge of its medicinal properties. The fraction obtained from the stem bark of S. joazeiro was analyzed by UPLC-QTOF-MS/MS, in which compounds such as triterpenoids, flavonoids, acids, and saponins were identified. Therefore, the results obtained in this study contribute to understanding the antifungal potential of the S. joazeiro species fraction against fungal infections, especially those caused by Candida spp.
Thesagro:	Saponina Flavonóide Planta Medicinal Cândida Albicans Ziziphus Joazeiro
NAL Thesaurus:	Saponins Flavonoids Antifungal agents Candida tropicalis Candida krusei Fluconazole Ultra-performance liquid chromatography Mass spectrometry Minimum inhibitory concentration Bark
Palabras clave:	Sarcomphalus joazeiro UPLC-QTOF-MS/MS Fração enriquecida em saponinas Atividade antifúngica Casca do caule de Sarcomphalus joazeiro Modulação da atividade do fluconazol Antagonismo com fluconazol Saponin enriched fraction Antifungal activity Sarcomphalus joazeiro stem bark Fluconazole activity modulation Fluconazole antagonism
ISSN:	1099-0801
DOI:	https://doi.org/10.1002/bmc.70509
Tipo de Material:	Artigo de periódico
Acceso:	openAccess
Aparece en las colecciones:	Artigo em periódico indexado (CNPAT)