Title:	Bioinspired Engineering ofBombyx mori Silk Fibroin:Solution Blow-Spun Nanofibers Hybridized with (3-Aminopropyl) triethoxysilane.
Authors:	SORIGOTTI, A. R. PASCHOALIN, R. T. SILVA, R. R. da FERNANDES, R. F. BARUD, H. da S. RIBEIRO, S. J. L. OLIVEIRA JR, O. N. OTONI, C. G. MATTOSO, L. H. C.
Affiliation:	UNIVERSITY OF SÃO PAULO (USP); NANOSCIENTIFCA SCANDINAVIAN AB, GOTHENBURG 41 390, SWEDEN; CENTRO UNIVERSITÁRIO DE ARARAQUARA; INSTITUTE OF CHEMISTRY, SÃO PAULO STATE UNIVERSITY (UNESP); SÃO CARLOS INSTITUTE OF PHYSICS (IFSC), UNIVERSITY OF SÃO PAULO (USP); FEDERAL UNIVERSITY OF SÃO CARLOS (UFSCAR); LUIZ HENRIQUE CAPPARELLI MATTOSO, CNPDIA.
Date Issued:	2026
Citation:	ACS Applied Bio Materials, v. 9, 2026.
Pages:	4170−4181
Description:	Thedevelopmentofbioinspirednanofibrousscaffoldswithadjustablefunctionsisessential forarangeofapplications, fromtissueengineeringtosustainablematerialsthatexploitthehierarchicalarchitecturesofBombyxmorisilks.Inthiswork,wereport theproductionoforganic−inorganicnanofibersbyincorporatingtheorganosilane(3-aminopropyl)triethoxysilane(APTES)intosilk fibroinusingthesolutionblowspinning(SB-spinning)technique.TheincorporationofAPTESaimstomodulatesolutionrheological properties,promoteconformational transitiontoβ-sheet-richstructures,andincreasethethermal stabilityof theresultingnanofiber, makingthemmoresuitableforbiomedicalapplications.SilkfibroinwasisolatedfromB.moricocoons,dissolvedinaternaryCaCl2/ EtOH/H2Osolution,andhybridizedwithAPTESbeforefiberproduction.Theresultingnanofibersdisplayedsmooth,uniformmor phologies andnanoscalediameters, confirming theeffectivenessof SB-spinning for creatinghybridsystems.Rheological analyses showedthataddingAPTESreducedviscosityandenhancedtheprocessabilityoffibroinsolutions.SpectroscopicandX-raydiffraction datarevealedanincreasedβ-sheetcontentandcrystallinityinthehybridfibers,whilethermogravimetricanalysisindicatedimproved thermal stability.Overall, theseresultsdemonstrate that incorporatingAPTESeffectivelyalters thephysicochemical andstructural propertiesofsilkfibroin,enablingtheproductionofpromisingnanofibrousscaffoldsforbiomedicalapplications.Thisstudythusintro ducesanapproachtoengineeringorganic−inorganichybridbiomaterialsviaascalable, low-costspinningprocess. KEYWORDS: biopolymers, solutionblowspinning,APTES,hybridnanofibers, tissueengineering
Keywords:	FIbroin nanofibers APTES
DOI:	https://doi.org/10.1021/acsabm.6c00155
Type of Material:	Artigo de periódico
Access:	openAccess
Appears in Collections:	Artigo em periódico indexado (CNPDIA)